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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK6
All Species:
9.09
Human Site:
S222
Identified Species:
14.29
UniProt:
Q00534
Number Species:
14
Phosphosite Substitution
Charge Score:
0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00534
NP_001138778.1
326
36938
S222
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001116412
303
33725
N217
R
K
P
L
F
C
G
N
S
E
A
D
Q
L
G
Dog
Lupus familis
XP_852360
326
36788
S222
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
Cat
Felis silvestris
Mouse
Mus musculus
Q64261
326
37010
S222
R
K
P
L
F
R
G
S
S
D
V
D
Q
L
G
Rat
Rattus norvegicus
P35426
303
33780
N217
R
K
P
L
F
C
G
N
S
E
A
D
Q
L
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511310
202
22667
E117
V
I
G
L
P
G
D
E
D
W
P
S
D
V
A
Chicken
Gallus gallus
P13863
303
34670
D207
K
K
P
L
F
H
G
D
S
E
I
D
Q
L
F
Frog
Xenopus laevis
Q91727
319
35666
N217
R
K
P
L
F
C
G
N
S
E
A
D
Q
L
C
Zebra Danio
Brachydanio rerio
NP_001137525
302
33962
L216
E
M
F
R
R
R
P
L
F
R
G
N
S
D
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477196
317
36383
F231
M
F
N
R
R
A
L
F
P
G
T
S
E
K
N
Honey Bee
Apis mellifera
XP_391955
457
50351
F371
L
S
R
L
E
P
L
F
P
G
T
S
E
G
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999689
373
42086
Q223
R
R
P
L
F
R
G
Q
S
D
K
D
Q
L
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
D207
Q
K
P
L
F
P
G
D
S
E
I
D
E
L
F
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
D207
Q
K
P
L
F
P
G
D
S
E
I
D
Q
L
F
Baker's Yeast
Sacchar. cerevisiae
P00546
298
34043
F212
M
C
N
R
K
P
I
F
S
G
D
S
E
I
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
65.6
96.6
N.A.
96.3
65
N.A.
56.1
43.5
65.3
76
N.A.
42.6
37.6
N.A.
50.6
Protein Similarity:
100
N.A.
76
97.5
N.A.
98.1
76
N.A.
58.5
61.9
77.9
83.1
N.A.
63.7
50.5
N.A.
63
P-Site Identity:
100
N.A.
73.3
100
N.A.
100
73.3
N.A.
6.6
60
66.6
6.6
N.A.
0
6.6
N.A.
73.3
P-Site Similarity:
100
N.A.
86.6
100
N.A.
100
86.6
N.A.
13.3
80
80
13.3
N.A.
6.6
13.3
N.A.
80
Percent
Protein Identity:
N.A.
44.4
N.A.
44.7
40.1
N.A.
Protein Similarity:
N.A.
62.2
N.A.
62.2
59.8
N.A.
P-Site Identity:
N.A.
53.3
N.A.
60
6.6
N.A.
P-Site Similarity:
N.A.
80
N.A.
80
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
7
0
0
0
0
20
0
0
0
7
% A
% Cys:
0
7
0
0
0
20
0
0
0
0
0
0
0
0
7
% C
% Asp:
0
0
0
0
0
0
7
20
7
27
7
67
7
7
14
% D
% Glu:
7
0
0
0
7
0
0
7
0
40
0
0
27
0
0
% E
% Phe:
0
7
7
0
67
0
0
20
7
0
0
0
0
0
20
% F
% Gly:
0
0
7
0
0
7
67
0
0
20
7
0
0
7
34
% G
% His:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
7
% H
% Ile:
0
7
0
0
0
0
7
0
0
0
20
0
0
7
0
% I
% Lys:
7
60
0
0
7
0
0
0
0
0
7
0
0
7
0
% K
% Leu:
7
0
0
80
0
0
14
7
0
0
0
0
0
67
0
% L
% Met:
14
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
14
0
0
0
0
20
0
0
0
7
0
0
7
% N
% Pro:
0
0
67
0
7
27
7
0
14
0
7
0
0
0
0
% P
% Gln:
14
0
0
0
0
0
0
7
0
0
0
0
60
0
0
% Q
% Arg:
47
7
7
20
14
34
0
0
0
7
0
0
0
0
0
% R
% Ser:
0
7
0
0
0
0
0
20
74
0
0
27
7
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
14
0
0
0
0
% T
% Val:
7
0
0
0
0
0
0
0
0
0
20
0
0
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _